Melitracen hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

美利曲辛盐酸盐是一种抗抑郁药，可作为潜在的多巴胺 D1/2 受体拮抗剂来治疗抑郁症。

Melitracen HCl ia potential dopamine D1/2 receptor antagonist used to treat depression. It is often co-administered with flupenthixol as a treatment for trigeminal neuralgia. It does not effect cardiovascular function.(In Vivo):Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals.No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased.

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Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracenproduces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals. No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased.

N 7001 | N7001 | N-7001 | Melitracen HCl

GPCR/G Protein

Antibacterial

D1|D2

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10563-70-9

327.9

C21H26ClN

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (304.98 mM)

Cl.CN(C)CC\C=C2/c1ccccc1C(C)(C)c3ccccc23

3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine hydrochloride

(-20℃)

With Ice Pack

≥ 2 years